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Transcriptional profile in SK-LM_S1 cells mediated by abrogation of MAPK7 and VCAN gene expression [Part 1]

GSE289613 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2026/02/13 Platform GPL28038
Summary
The ERK5 signaling pathway has emerged as a novel key player in soft tissue sarcoma biology, mediating tumour growth and progression. Here we show how the expression of VCAN, a member of the chondroitin sulphate proteoglycan family, is modulated by the ERK5 pathway at the transcriptional level and mediates biological processes such as migration, adhesion, proliferation and tumourigenesis in vivo. This conclusion is based on genetic (shRNA, overexpression) and pharmacological approaches using the human soft tissue sarcoma cell lline Sk-LM-S1 a. In particular, VCAN knockdown mimics ERK5 knockdown in vitro and in vivo, whereas VCAN overexpression restores the phenotypes observed after ERK5 knockdown. In addition, transcriptomic studies show that VCAN is a central mediator in the ERK5-associated transcriptional landscape, supporting its role in diverse biological processes. Taken together, these data support VCAN as a new key target in the ERK5 pathway.
Published in
VCAN Is Essential for ERK5-Driven Tumorigenesis in Soft Tissue Sarcoma
Jiménez-Suárez J, Cimas FJ, Paricio JJ et al. · International journal of biological sciences 2026 · PMID 41800245 · doi:10.7150/ijbs.121402
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Also filed as BioProject PRJNA1223819 and SRA study SRP563964. Searching any of these in the dataset finder brings you back here.

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