IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR-mutant non–small cell lung cancer II
RNA-seq (gene expression) · human · 32 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Lung cancerThis series is part of our curated briefing on it.
- Samples
- 32 samples: 32 × FFPE tumor sectionGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR-mutant non-small cell lung cancerMolecular cancer · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE289619_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1223832 and SRA study SRP563969. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 32 samples.
How we read this: 1 replicated groups read from 32 sample titles; they account for 32 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8795114 FFPE tumor section_1 FFPE tumor section
- GSM8795115 FFPE tumor section_2 FFPE tumor section
- GSM8795116 FFPE tumor section_3 FFPE tumor section
- GSM8795117 FFPE tumor section_4 FFPE tumor section
- GSM8795118 FFPE tumor section_5 FFPE tumor section
- GSM8795119 FFPE tumor section_6 FFPE tumor section
- GSM8795120 FFPE tumor section_7 FFPE tumor section
- GSM8795121 FFPE tumor section_8 FFPE tumor section
- GSM8795122 FFPE tumor section_9 FFPE tumor section
- GSM8795123 FFPE tumor section_10 FFPE tumor section
- GSM8795124 FFPE tumor section_11 FFPE tumor section
- GSM8795125 FFPE tumor section_12 FFPE tumor section
- GSM8795126 FFPE tumor section_13 FFPE tumor section
- GSM8795127 FFPE tumor section_14 FFPE tumor section
- GSM8795128 FFPE tumor section_15 FFPE tumor section
- GSM8795129 FFPE tumor section_16 FFPE tumor section
- GSM8795130 FFPE tumor section_17 FFPE tumor section
- GSM8795131 FFPE tumor section_18 FFPE tumor section
- GSM8795132 FFPE tumor section_19 FFPE tumor section
- GSM8795133 FFPE tumor section_20 FFPE tumor section
- GSM8795134 FFPE tumor section_21 FFPE tumor section
- GSM8795135 FFPE tumor section_22 FFPE tumor section
- GSM8795136 FFPE tumor section_23 FFPE tumor section
- GSM8795137 FFPE tumor section_24 FFPE tumor section
- GSM8795138 FFPE tumor section_25 FFPE tumor section
- GSM8795139 FFPE tumor section_26 FFPE tumor section
- GSM8795140 FFPE tumor section_27 FFPE tumor section
- GSM8795141 FFPE tumor section_28 FFPE tumor section
- GSM8795142 FFPE tumor section_29 FFPE tumor section
- GSM8795143 FFPE tumor section_30 FFPE tumor section
- GSM8795144 FFPE tumor section_31 FFPE tumor section
- GSM8795145 FFPE tumor section_32 FFPE tumor section
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.