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The effect of PROTAC-mediated depletion of TAF1 on gene expression

GSE289670 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/01 Platform GPL16791
Summary
The goal of this experiment was to determine the change in gene expression after transient depletion of the TAF1 transcription factor (aka TFII-250) using a PROTAC molecule (ZS3-046) containing GNE371 as TAF1 ligand and pomalidomide as CRBN ligand.
Published in
PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits Tumor Growth In Vivo
Chen L, Shultz ZP, Sansone M et al. · Molecular cancer therapeutics 2025 · PMID 40376796 · doi:10.1158/1535-7163.MCT-24-1091
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Also filed as BioProject PRJNA1223918 and SRA study SRP564030. Searching any of these in the dataset finder brings you back here.

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