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Human PSC-based Modeling of Pulmonary Fibrosis Identifies p300/CBP Inhibition as a Suppressor of Alveolar Transitional Cell State [epithelial]

GSE289676 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2026/02/18 Platform GPL30173
Summary
In this study, we conducted a drug screening using an in vitro pulmonary fibrosis model and identified p300/CBP inhibitors as candidate therapeutic agents. We investigated the mechanisms underlying the emergence of the alveolar transitional cell state (ATCS) with human PSC-derived alveolar organoids.
Published in
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State
Tsutsui Y, Masui A, Konishi S et al. · Nature communications 2026 · PMID 41680175 · doi:10.1038/s41467-026-68909-z
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Also filed as BioProject PRJNA1223922 and SRA study SRP564032. Searching any of these in the dataset finder brings you back here.

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