Ageing promotes metastasis via activation of the integrated stress response [RNA-Seq OE]
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × Y2_ctrl vs 4 × Y2_OE vs 4 × A1_ctrl vs 4 × A1_OEGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Ageing promotes metastasis via activation of the integrated stress responseNature · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE289768_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1224753 and SRA study SRP564352. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8798215 Y2_ctrl_1 Y2_ctrl
- GSM8798216 Y2_ctrl_2 Y2_ctrl
- GSM8798217 Y2_ctrl_3 Y2_ctrl
- GSM8798218 Y2_ctrl_4 Y2_ctrl
- GSM8798219 Y2_OE_1 Y2_OE
- GSM8798220 Y2_OE_2 Y2_OE
- GSM8798221 Y2_OE_3 Y2_OE
- GSM8798222 Y2_OE_4 Y2_OE
- GSM8798223 A1_ctrl_1 A1_ctrl
- GSM8798224 A1_ctrl_2 A1_ctrl
- GSM8798225 A1_ctrl_3 A1_ctrl
- GSM8798226 A1_ctrl_4 A1_ctrl
- GSM8798227 A1_OE_1 A1_OE
- GSM8798228 A1_OE_2 A1_OE
- GSM8798229 A1_OE_3 A1_OE
- GSM8798230 A1_OE_4 A1_OE
- GSE263688 Ageing promotes metastasis via activation of the integrated stress response 16 samples shares metastasis, activation, integrated, promotes, ageing, stress
- GSE335147 Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response 24 samples shares integrated, stress
- GSE243942 Spatio-temporal X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing [RNA-seq] 125 samples shares activation, rna-seq
- GSE245648 The Heme-regulated transcriptional repressor, BACH1 safeguards macrophage enhancer selection, activation andtissue adaptation [RNA-seq_BMDM] 24 samples shares activation, rna-seq
- GSE227108 Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells (scRNA-seq) 18 samples shares integrated, rna-seq
- GSE288348 Disease-associated astrocyte epigenetic memory promotes CNS pathology [sgEp300, sgACLY astrocytes bulk RNA-Seq dataset] 18 samples shares promotes, rna-seq
- GSE230838 Loss of cisPTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma [RNA-seq] 17 samples shares promotes, rna-seq
- GSE313021 STING–IFN–CH25H lipid axis links innate immune activation to tau pathology [scRNA-seq] 16 samples shares activation, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.