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Single-cell profiling of liver in offspring with intrauterine hyperglycemia reveals acute-phase response deficiency

GSE289783 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/10/21 Platform GPL24247
Summary
Gestational diabetes mellitus (GDM) has long-term effects on the offspring health. Among these chronic diseases, inflammatory profiles play important roles in their development. Assessment for inflammatory status of GDM offspring is limited. Thus, the single cell RNA sequencing (scRNA-seq) was conducted to delineate the inflammatory characteristics of offspring with intrauterine hyperglycemia (IHG). scRNA-seq analysis of mice liver revealed myeloid polarization and multiple lineages developmental retardationwas identified in IHG offspring. Proinflammatory potential of myeloid cells seemed to be deeply imprinted in the liver of adult offspring with IHG.
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Also filed as BioProject PRJNA1224778 and SRA study SRP564380. Searching any of these in the dataset finder brings you back here.

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