GEO series
The role and mechanism of hypoxia-induced SLC6A8 up-regulation in HCC progression
GSE289804
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2025/07/23
GPL34284
Summary
Hypoxia is a hallmark of solid tumors and profoundly affects the malignant phenotypes of cancer cells. We find that the creatine transporter solute carrier family 6, member 8 (SLC6A8) is upregulated in hypoxic HCC cells. Hypoxia-induced creatine accumulation drives metabolic reprogramming and antagonizes parthanatos. Pharmacological inhibition of SLC6A8 represents a promising therapeutic strategy for HCC.
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