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Inhalable liposomal delivery of osimertinib and DNA for treating primary and metastatic lung cancer

GSE289979 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/10 Platform GPL24247
Summary
Lung cancer is one of the most prevalent cancers, and brain metastases significantly worsen the prognosis for patients. We developed an inhalable surfactant-based biomimetic nanoliposome system (MPDOLs) to co-deliver Osimertinib and DNA plasmids to deplete IGF2BP3 expression. To investigate how MPDOLs influence gene expression and therapeutic outcomes by targeting IGF2BP3 and co-delivering Osimertinib, we performed transcriptomic analysis of MPDOL treated Lewis lung cancer cells.
Published in
Inhalable liposomal delivery of osimertinib and DNA for treating primary and metastasis lung cancer
Fu X, Shi Y, Wu H et al. · Nature communications 2025 · PMID 40199846 · doi:10.1038/s41467-025-58312-5
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Also filed as BioProject PRJNA1225676 and SRA study SRP564993. Searching any of these in the dataset finder brings you back here.

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