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Transcriptome profiling of human bladder cancer cell line RT112 infected with lentivirus expressing either an shRNA targeting ELOVL6 (shE6) or a scrambled shRNA (shCtrl)

GSE290017 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/06/02 Platform GPL24676
Summary
ELOVL6 is a member of mammalian fatty acid elongase family responsible for converting C16 saturated and monounsaturated fatty acids into C18 species. To investigate the role of ELOVL6 in human bladder cancer, we generated RT112 cells (a human bladder cancer cell line) infected with lentivirus expressing either an shRNA targeting ELOVL6 (shE6) or a scrambled shRNA (shCtrl). The aim of this experiment was to assess the effects of ELOVL6 knockdown on the transcriptome of human bladder cancer cells.
Published in
Inhibition of ELOVL6 activity impairs mitochondrial respiratory function and inhibits tumor progression in FGFR3-mutated bladder cancer cells
Matsuda E, Hasebe S, Matsuzaka T et al. · Biochimica et biophysica acta. Molecular basis of disease 2025 · PMID 40835210 · doi:10.1016/j.bbadis.2025.168023
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Also filed as BioProject PRJNA1225448 and SRA study SRP564846. Searching any of these in the dataset finder brings you back here.

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