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CEBPB-high dormant tumor cells drive immune evasion [RNA-Seq]

GSE290038 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/21 Platform GPL13112
Summary
Triple negative breast cancer (TNBC) poorly responds to immune checkpoint blockade (ICB) therapy. Dormant tumor cells are recognized as immunotherapy-resistant reservoirs, potential leading to tumor relapse, highlighting the importance to elucidate the mechanisms underlying immunotherapy resistance. Herein, we demonstrated that dormant tumor cells were resistant to ICB therapy and occupied an immunosuppressive niche with enhanced tumor-associated macrophages (TAMs) and decreased CD8+T cells infiltration in mouse TNBC allografts via a label-retention system. CEBPB was highly expressed in dormant tumor cells and maintained tumor dormancy by transcriptionally activating cell cycle negative regulators like CCNG2 and p27.
Published in
CEBPB-high dormant tumor cells drive immune evasion via S100A8 orchestrated tumor-associated macrophages reprogramming
Bai J, Su H, Wang S et al. · Theranostics 2026 · PMID 41799200 · doi:10.7150/thno.124789
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Also filed as BioProject PRJNA1225951 and SRA study SRP565196. Searching any of these in the dataset finder brings you back here.

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