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Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis

GSE290055 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/02/27 Platform GPL13112
Summary
We have employed single-cell RNA sequencing using the 10x Genomics platform to investigate the immune cell distribution in the liver of Sedentary (Sed) and preoperative exercise (PEx) mice following surgical stress-promoted colorectal cancer liver metastasis model. The liver immune microenvironment plays a critical role in tumor progression and response to PEx. This study provides a comprehensive immune landscape at single-cell resolution, offering novel insights into how PEx modulates hepatic immune cell populations to mitigate surgical stress-induced tumor progression.
Published in
Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis
Zhang Y, Zhang Y, Shen C et al. · Cell reports. Medicine 2026 · PMID 41666921 · doi:10.1016/j.xcrm.2026.102589
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Also filed as BioProject PRJNA1226112 and SRA study SRP565276. Searching any of these in the dataset finder brings you back here.

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