Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site selection [RNA-Seq]
RNA-seq (gene expression) · human · 92 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 92 samples: 92 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site selectionMolecular cell · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE290282_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1227128 and SRA study SRP565737. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 80 samples read as cases, 12 as controls.
How we read this: Read from 92 sample titles: 92 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8809714 AKNAK knockdown, rep1, group B
- GSM8809715 AKNAK knockdown, rep2, group B
- GSM8809716 CNOT2 knockdown, rep1, group A
- GSM8809717 CNOT2 knockdown, rep2, group A
- GSM8809718 CPSF6 knockdown, rep1, group A
- GSM8809719 CPSF6 knockdown, rep2, group A
- GSM8809720 DZIP3 knockdown, rep1, group A
- GSM8809721 DZIP3 knockdown, rep2, group A
- GSM8809722 EIF4B knockdown, rep1, group A
- GSM8809723 EIF4B knockdown, rep2, group A
- GSM8809724 GRB2 knockdown, rep1, group A
- GSM8809725 GRB2 knockdown, rep2, group A
- GSM8809726 HNRNPF knockdown, rep1, group A
- GSM8809727 HNRNPF knockdown, rep2, group A
- GSM8809728 HNRNH2 knockdown, rep1, group B
- GSM8809729 HNRNH2 knockdown, rep2, group B
- GSM8809730 LGALS3 knockdown, rep1, group A
- GSM8809731 LGALS3 knockdown, rep2, group A
- GSM8809732 LSM10 knockdown, rep1, group B
- GSM8809733 LSM10 knockdown, rep2, group B
- GSM8809734 LSM1 knockdown, rep1, group A
- GSM8809735 LSM1 knockdown, rep2, group A
- GSM8809736 MBNL1 knockdown, rep1, group A
- GSM8809737 MBNL1 knockdown, rep2, group A
- GSM8809738 MBNL2 knockdown, rep1, group A
- GSM8809739 MBNL2 knockdown, rep2, group A
- GSM8809740 NUDT21(CPSF5) knockdown, rep1, group A
- GSM8809741 NUDT21(CPSF5) knockdown, rep2, group A
- GSM8809742 PARN knockdown, rep1, group A
- GSM8809743 PARN knockdown, rep2, group A
- GSM8809744 PCBP1 knockdown, rep1, group B
- GSM8809745 PCBP1 knockdown, rep2, group B
- GSM8809746 PCBP3 knockdown, rep1, group A
- GSM8809747 PCBP3 knockdown, rep2, group A
- GSM8809748 PPIA knockdown, rep1, group A
- GSM8809749 PPIA knockdown, rep2, group A
- GSM8809750 PPP1CA knockdown, rep1, group A
- GSM8809751 PPP1CA knockdown, rep2, group A
- GSM8809752 PRPF4 knockdown, rep1, group B
- GSM8809753 PRPF4 knockdown, rep2, group B
+ 52 more — browse all 92 samples with per-sample file links →
- GSE290248 Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site selection 97 samples shares large-scale, rna-binding, regulators, selection, tethered, proteins, screen
- GSE279032 Genome-wide CRISPR screen identifies Menin and SUZ12 as regulators of human developmental timing [RNA-seq] 60 samples shares regulators, rna-seq, screen
- GSE100637 Large-scale tethering of RNA binding proteins discovers alternative splicing regulators [RIP-Seq] 48 samples shares large-scale, regulators, proteins
- GSE311641 Oncofetal RNA-binding proteins IGF2BP suppress innate immune signaling pathways in leukemia stem cells [RNA-seq] 32 samples shares rna-binding, proteins, rna-seq
- GSE297338 Codon-dependent regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins [RNA-seq] 15 samples shares rna-binding, proteins, rna-seq
- GSE243935 High Density Domain-Focused CRISPR Screens Reveal Novel Epigenetic Regulators of HOX/MEIS Activation in Acute Myeloid Leukemia [RNA-seq, SGF29 KO vs. NTC in MOLM13 and U937] 12 samples shares regulators, rna-seq, screen
- GSE100638 Large-scale tethering of RNA binding proteins discovers alternative splicing regulators 220 samples shares large-scale, regulators, proteins
- GSE268946 RNA-binding proteins DND1 and NANOS3 coordinately suppress SOX4 in processing bodies for restricting the entry of germ cell lineage 36 samples shares rna-binding, proteins
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.