Oncostatin M drives multifaceted immune pathogenesis in atopic dermatitis-like inflammation via neutrophil-dependent mechanisms
Single-cell RNA-seq · mouse · 16 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 5 × WT Skin con vs 5 × WT Skin MC903 vs 3 × WT AD Skin anti OSM vs 3 × WT AD Skin anti Ly6GGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE290386_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1227867 and SRA study SRP566278. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8811746 WT Skin con 1 WT Skin con
- GSM8811747 WT Skin con 2 WT Skin con
- GSM8811748 WT Skin con 3 WT Skin con
- GSM8811749 WT Skin con 4 WT Skin con
- GSM8811750 WT Skin con 5 WT Skin con
- GSM8811751 WT Skin MC903 1 WT Skin MC903
- GSM8811752 WT Skin MC903 2 WT Skin MC903
- GSM8811753 WT Skin MC903 3 WT Skin MC903
- GSM8811754 WT Skin MC903 4 WT Skin MC903
- GSM8811755 WT Skin MC903 5 WT Skin MC903
- GSM9239991 WT AD Skin anti OSM 1 WT AD Skin anti OSM
- GSM9239992 WT AD Skin anti OSM 2 WT AD Skin anti OSM
- GSM9239993 WT AD Skin anti OSM 3 WT AD Skin anti OSM
- GSM9239994 WT AD Skin anti Ly6G 1 WT AD Skin anti Ly6G
- GSM9239995 WT AD Skin anti Ly6G 2 WT AD Skin anti Ly6G
- GSM9239996 WT AD Skin anti Ly6G 3 WT AD Skin anti Ly6G
- GSE295168 Identification of Pre-Disease State in NC/Nga Mice with Atopic dermatitis-like Symptoms using Dynamical Network Biomarkers 190 samples shares dermatitis-like, atopic
- GSE248275 Adenosine triggers early astrocyte reactivity that provokes microglial reaction and drives the pathogenesis of sepsis-associated encephalopathy 18 samples shares pathogenesis, drives
- GSE327604 Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis [RNA-Seq] 12 samples shares pathogenesis, drives
- GSE295000 TLR9/NF-κB-Mediated Dendritic Cell Activation by Neutrophil Extracellular Traps Drives Pathogenesis in Experimental Cerebral Malaria 6 samples shares pathogenesis, drives
- GSE327611 Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis [scRNA-Seq] 4 samples shares pathogenesis, drives
- GSE190309 Single nuclei RNA and ATAC sequencing of mouse trigeminal ganglia at baseline and in atopic dermatitis-like disease. 14 samples shares dermatitis-like, atopic
- GSE327608 Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis [Cut & Tag] 6 samples shares pathogenesis, drives
- GSE283666 Gut Commensal Parabacteroides goldsteinii mitigates LRRK2 Parkinsonism through reducing neuroinflammation and multifaceted effects on gut homeostasis [RNA-seq] 54 samples shares multifaceted
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.