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Rapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [Nanopore]

GSE290441 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/03/07 Platform GPL26167
Summary
In this study, we describe the development of a new model of TDP43 proteinopathy using human induced pluripotent stem cell (iPSC)-derived neurons. Utilizing a genome engineering approach, we induced the mislocalization of endogenous TDP43 from the nucleus to the cytoplasm without mutating the TDP43 gene or using chemical stressors
Published in
Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis
Ganssauge J, Hawkins S, Namboori SC et al. · eLife 2025 · PMID 40704991 · doi:10.7554/eLife.95062
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Also filed as BioProject PRJNA1228031 and SRA study SRP566214. Searching any of these in the dataset finder brings you back here.

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