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Role of mucin MUC5AC on tumor angiogenesis and lung adenocarcinoma development

GSE290456 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/15 Platform GPL24676
Summary
MUC5AC is a secretory type of mucin, which is significantly overexpressed in lung adenocarcinoma and associated with poor survival outcomes. Expression of MUC5AC and its sialylation is required for alteration of tumor matrix remodeling through interacting with integrin β4 in lung adenocarcinoma. We have previously shown that sialylated MUC5AC is required for lung adenocarcinoma cell growth and metastasis. To understand the molecular mechanism of MUC5AC in lung adenocarcinoma development, we performed RNA sequence analysis using MUC5AC knockdown cells (A549-shMUC5AC) and scramble cells (A549-shRNA). We observed that several tumor matrix proteins including VCAN and integrin β4 were significantly downregulated and are associated with tumor angiogenesis. In this study, we reported that sialylated MUC5AC induces tumor angiogenesis by altering tumor matrix protein VCAN during lung adenocarcinoma development and metastasis.
Published in
ST6GalNAc-I regulates tumor cell sialylation via NECTIN2/MUC5AC-mediated immunosuppression and angiogenesis in non-small cell lung cancer
Appadurai MI, Chaudhary S, Shah A et al. · The Journal of clinical investigation 2025 · PMID 40371640 · doi:10.1172/JCI186863
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Also filed as BioProject PRJNA1228070 and SRA study SRP566240. Searching any of these in the dataset finder brings you back here.

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