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Liver metastases license neutrophils throygh IL-1 to potentiate cancer progression

GSE290489 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/08/04 Platform GPL24247
Summary
Liver metastases are associated with poor cancer outcomes in many solid malignancies, but the factors influencing the trajectory of patients with liver metastases are poorly defined. It is known that liver metastases suppress systemic antitumor immunity; however, the underlying mechanisms remain incompletely described. We report that liver metastases promote disease progression in patients and preclinical models. Patients with liver metastases progress rapidly, regardless of primary tumor type. In multiple murine models, we find that liver metastases potentiate neutrophil migration and activity. Neutrophils licensed by liver metastasis augment metastatic colonization in an IL-1 dependent fashion. Thus, liver metastasis rewires systemic immunity to promote cancer progression. This work has implications for novel treatment strategies to address the poor clinical outcomes associated with liver metastasis.
Published in
Liver Metastases License Neutrophils through IL1 to Potentiate Cancer Progression
Pearson AN, Waninger J, Huber AK et al. · Cancer immunology research 2025 · PMID 40906822 · doi:10.1158/2326-6066.CIR-24-1074
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Also filed as BioProject PRJNA1228252 and SRA study SRP566310. Searching any of these in the dataset finder brings you back here.

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