miRNA/mRNA analysis of Chlamydia trachomatis-infected endometrial biopsies indicate increased TGF-β pathways drive epithelial-mesenchymal transition and regulatory T cell differentiation
RNA-seq (gene expression) · human · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 15 samples: 4 × Endo+, Clinical PID+, # vs 4 × Endo-, # vs 4 × Uninfected, # vs 3 × Endo+, Clinical PID-, #Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- miRNA/mRNA analysis of increased TGF-β pathways drive epithelial-mesenchymal transition and regulatory T cell differentiationbioRxiv : the preprint server for biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE290615_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1229085 and SRA study SRP566624. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 4 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8818218 Endo+, Clinical PID+, #1 Endo+, Clinical PID+, #
- GSM8818219 Endo+, Clinical PID+, #2 Endo+, Clinical PID+, #
- GSM8818220 Endo+, Clinical PID+, #3 Endo+, Clinical PID+, #
- GSM8818221 Endo+, Clinical PID+, #4 Endo+, Clinical PID+, #
- GSM8818222 Endo+, Clinical PID-, #1 Endo+, Clinical PID-, #
- GSM8818223 Endo+, Clinical PID-, #2 Endo+, Clinical PID-, #
- GSM8818224 Endo+, Clinical PID-, #3 Endo+, Clinical PID-, #
- GSM8818225 Endo-, #1 Endo-, #
- GSM8818226 Endo-, #2 Endo-, #
- GSM8818227 Endo-, #3 Endo-, #
- GSM8818228 Endo-, #4 Endo-, #
- GSM8818229 Uninfected, #1 Uninfected, #
- GSM8818230 Uninfected, #2 Uninfected, #
- GSM8818231 Uninfected, #3 Uninfected, #
- GSM8818232 Uninfected, #4 Uninfected, #
- GSE266169 Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multilineage biliary organoids 14 samples shares tgf, epithelial-mesenchymal, transition
- GSE255298 IL-2 and TGF-b1 promote regulatory activity in NK cells following Hematopoietic Stem Cell Transplantation 13 samples shares tgf, regulatory
- GSE290255 Key Regulatory Elements of the TGFβ-LRRC15 Axis Predict Disease Progression and Immunotherapy Resistance Across Cancer Types 12 samples shares tgf, regulatory
- GSE256412 Epigenetic changes regulating the epithelial-mesenchymal transition in human trophoblast differentiation 22 samples shares epithelial-mesenchymal, transition
- GSE298139 Therapy-resistance in AT/RT is driven by epithelial-mesenchymal transition, extracellular matrix changes, and enrichment of CD1A+ CD207+ dendritic cells [snRNA-seq] 16 samples shares epithelial-mesenchymal, transition
- GSE298140 Therapy-resistance in AT/RT is driven by epithelial-mesenchymal transition, extracellular matrix changes, and enrichment of CD1A+ CD207+ dendritic cells [RNA-seq_FFPE] 12 samples shares epithelial-mesenchymal, transition
- GSE239418 SAMD1 suppresses epithelial-mesenchymal transition pathways in pancreatic ductal adenocarcinoma 12 samples shares epithelial-mesenchymal, transition
- GSE237690 Lupus dermal fibroblasts hyper-respond to inflammatory cytokines and exhibit a pro-fibrotic phenotype to TGF-β in patients with scarring skin disease 317 samples shares tgf
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.