Shared roles of immune and stromal cells in the pathogenesis of human bronchiolitis obliterans syndrome
Single-cell RNA-seq · human · 21 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 21 samples: 20 distinct titles, 1 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Shared roles of immune and stromal cells in the pathogenesis of human bronchiolitis obliterans syndromeJCI insight · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE290834_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1230197. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 21 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8823747 R710000595_CD45neg
- GSM8823748 R710000595_CD45pos
- GSM8823749 R710000755_CD45neg
- GSM8823750 R710000755_CD45pos
- GSM8823751 R710000738_CD45neg
- GSM8823752 R710000738_CD45pos
- GSM8823753 R710000625_CD45neg
- GSM8823754 R710000625_CD45pos
- GSM8823755 R710000652_CD45neg_1
- GSM8823756 R710000652_CD45neg_2
- GSM8823757 R710000652_CD45pos
- GSM8823758 R710000705_CD45neg
- GSM8823759 R710000705_CD45pos
- GSM8823760 R710000715_CD45neg
- GSM8823761 R710000715_CD45pos
- GSM8823762 GL0000189_CD45neg
- GSM8823763 GL0000189_CD45pos
- GSM8823764 GL0000171_CD45neg
- GSM8823765 GL0000171_CD45pos
- GSM8823766 GL0000267_CD45neg
- GSM8823767 GL0000267_CD45pos
- GSE327957 Transcriptome profiling of induced sputum identified up-regulated TNF-α/NF-κB signaling and down-regulated mitochondrial respiratory chain function in post-infectious Bronchiolitis obliterans 17 samples shares bronchiolitis, obliterans
- GSE249301 Cardiomyocytes and stromal cells cross-talk influences the pathogenesis of arrhythmogenic cardiomyopathy: a multi-level analysis uncovers DLK1-NOTCH pathway role in fibro-adipose remodeling 12 samples shares pathogenesis, stromal
- GSE277276 Immune Signaling Mediates Stromal Changes to Support Epithelial Reprogramming in Celiac Duodenum 34 samples shares stromal
- GSE273693 HDAC10 and Its Implications in Sézary Syndrome Pathogenesis 24 samples shares pathogenesis
- GSE253568 Regulatory T cells and IFN-γ-producing Th1 cells play a critical role in the pathogenesis of Sjögren’s Syndrome 17 samples shares pathogenesis
- GSE317680 Single Cell and Spatial Transcriptomics Identify Novel Immune-Stromal Interactions in Cardiac Allograft Vasculopathy 13 samples shares stromal
- GSE273559 Single-cell profiling of prurigo nodularis demonstrates immune-stromal crosstalk driving profibrotic responses and reversal with nemolizumab 12 samples shares stromal
- GSE335482 Immune-dominated cellular heterogeneity and stromal plasticity in keloid infiltrating and hypercellular zones revealed by single-cell RNA sequencing 8 samples shares stromal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.