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Immune cell sequencing after allogeneic hematopoietic cell transplantation

GSE290836 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/03/01 Platform GPL24676
Summary
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for hematologic malignancies. The primary non-relapse complication after allo-HSCT is graft-versus-host disease (GVHD). The use of T regulatory (Treg) cells to prevent GVHD has emerged as a promising allogeneic T cell immunotherapy in the form of Orca-T. However, the precise differences in immune states which may influence clinical outcomes after Orca-T compared with unmanipulated peripheral blood stem cell (PBSC) grafts remain unexplored. Using peripheral blood specimens longitudinally collected between 3 weeks and one year after leukemia treatment, we examined single-cell mRNA sequencing (scRNA-seq) analysis of 16 HLA-matched patients receiving either Orca-T or unmanipulated PBSC grafts.
Published in
Regulatory-like FOXP3+Helios+CD4+ T conventional cells correlate with T-cell activation after Orca-T immunotherapy
Bader CS, Killian S, Iliopoulou BP et al. · Blood 2026 · PMID 41758930 · doi:10.1182/blood.2025031545
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Also filed as BioProject PRJNA1229550 and SRA study SRP566834. Searching any of these in the dataset finder brings you back here.

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