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Analysis of local mucosal immune dysregulation to guide pilot directed therapy for long-COVID olfactory loss [5' GEX]

GSE290883 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/25 Platform GPL24676
Summary
To further define local mechanisms impacting peripheral olfactory structures, we obtained olfactory biopsies from subjects with post-COVID olfactory loss (hyposmia) or controls for viral, single cell and T cell receptor assays. Here we identified clonally expanded T cell subsets with a pro-inflammatory profile.
Published in
Analysis of mucosal immune dysregulation and safety and tolerability of endoscopic topical steroid therapy for long-COVID hyposmia: randomized, double-blinded pilot study
Kim S, D'Anniballe VM, Finlay JB et al. · Communications medicine 2025 · PMID 41461919 · doi:10.1038/s43856-025-01322-7
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Also filed as BioProject PRJNA1230710 and SRA study SRP567434. Searching any of these in the dataset finder brings you back here.

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