ZDHHC12 palmitoylates HDAC8 and promotes the development of hepatocellular carcinoma associated with a diet high in saturated fatty acids
RNA-seq (gene expression) · human · 30 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Hepatocellular carcinomaThis series is part of our curated briefing on it.
- Samples
- 30 samples: 15 × high red meat diet vs 15 × normal dietGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ZDHHC12 Palmitoylates HDAC8 to Promote the Progression of Hepatocellular Carcinoma Associated with a Diet High in Saturated Fatty AcidsAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE290907_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1230739 and SRA study SRP567452. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 30 samples.
How we read this: 2 replicated groups read from 30 sample titles; they account for 30 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8825061 high red meat diet 1 high red meat diet
- GSM8825062 high red meat diet 2 high red meat diet
- GSM8825063 high red meat diet 3 high red meat diet
- GSM8825064 high red meat diet 4 high red meat diet
- GSM8825065 high red meat diet 5 high red meat diet
- GSM8825066 high red meat diet 6 high red meat diet
- GSM8825067 high red meat diet 7 high red meat diet
- GSM8825068 high red meat diet 8 high red meat diet
- GSM8825069 high red meat diet 9 high red meat diet
- GSM8825070 high red meat diet 10 high red meat diet
- GSM8825071 high red meat diet 11 high red meat diet
- GSM8825072 high red meat diet 12 high red meat diet
- GSM8825073 high red meat diet 13 high red meat diet
- GSM8825074 high red meat diet 14 high red meat diet
- GSM8825075 high red meat diet 15 high red meat diet
- GSM8825076 normal diet1 normal diet
- GSM8825077 normal diet2 normal diet
- GSM8825078 normal diet3 normal diet
- GSM8825079 normal diet4 normal diet
- GSM8825080 normal diet5 normal diet
- GSM8825081 normal diet6 normal diet
- GSM8825082 normal diet7 normal diet
- GSM8825083 normal diet8 normal diet
- GSM8825084 normal diet9 normal diet
- GSM8825085 normal diet10 normal diet
- GSM8825086 normal diet11 normal diet
- GSM8825087 normal diet12 normal diet
- GSM8825088 normal diet13 normal diet
- GSM8825089 normal diet14 normal diet
- GSM8825090 normal diet15 normal diet
- GSE105130 Comprehensive analysis of Transcriptome Profiles in Hepatocellular Carcinoma patients 52 samples same disease briefing · shares hepatocellular
- GSE140228 Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma 41 samples same disease briefing · shares hepatocellular
- GSE14520 Gene expression data of human hepatocellular carcinoma (HCC) 488 samples same disease briefing · shares hepatocellular
- GSE10143 Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma 387 samples same disease briefing · shares hepatocellular
- GSE107170 Molecular Signature of Hepatitis D Virus-Associated Hepatocellular Carcinoma 307 samples same disease briefing · shares hepatocellular
- GSE109211 Molecular predictors of prevention of recurrence in hepatocellular carcinoma with sorafenib as adjuvant treatment in the phase 3 STORM trial 140 samples same disease briefing · shares hepatocellular
- GSE10186 Integrative Transcriptome Analysis Reveals Common Molecular Subtypes of Human Hepatocellular Carcinoma 118 samples same disease briefing · shares hepatocellular
- GSE114564 Identification of novel serum biomarkers in early-stage HCC patients. 118 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.