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EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism in human neural models

GSE291006 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/12/04 Platform GPL24676
Summary
EZHIP (Enhancer of Zeste Inhibitory Protein) is an enigmatic protein with no discernible domains, primarily known for its role in inhibiting PRC2-mediated H3K27 methylation. It is highly expressed in posterior fossa type A (PFA) ependymoma, where it drives global chromatin reorganization. Using human neural models, we show that EZHIP activates neuronal-like transcriptional programs while repressing genes involved in metabolic regulation. Metabolomic analyses indicate that EZHIP suppresses methionine and polyamine metabolism, potentially contributing to the histone and DNA methylation alterations observed in PFA. These findings highlight a metabolic dimension to EZHIP’s function and suggest that targeting polyamine metabolism may represent a therapeutic avenue for PFA.
Published in
EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism
Hasheminasabgorji E, Chen HM, Gatesman TA et al. · Acta neuropathologica communications 2025 · PMID 41204377 · doi:10.1186/s40478-025-02141-6
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Also filed as BioProject PRJNA1231362 and SRA study SRP567925. Searching any of these in the dataset finder brings you back here.

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