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Transcriptomic changes in the hypothalamus of gasping mice by high concentration of sevoflurane.

GSE291020 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/18 Platform GPL19057
Summary
Gasping respiration is a terminal pattern that occurs after anoxia effort in response to severe hypoxia, and has been known to increase the chances of survival in patients with cardiac arrest. During severe hypoxia, increased activity of upper airway muscles would be essential for self-resuscitation in association with gasping respiration. Previously, we reported that high concentration of sevoflurane, one of the volatile anesthetics, causes a gasping-like respiration pattern in mice. Herein, to extend understanding of the molecular mechanism involving the gasping respiration, we performed a comprehensive analysis of the changes in hypothalamic transcripts of sevoflurane-induced gasping mice.
Published in
Increased Orexin by High Concentration of Sevoflurane Enhances the Suprahyoid Muscle Activity Involves in Gasping-Like Respiration of Mice
Irukayama-Tomobe Y, Kim JD, Jin H et al. · FASEB bioAdvances 2026 · PMID 41573534 · doi:10.1096/fba.2025-00272
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Also filed as BioProject PRJNA1231407 and SRA study SRP567792. Searching any of these in the dataset finder brings you back here.

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