GEO series
To study the underlying molecular mechanisms causing the defect in megakaryocyte development by FLI1 p.Met100*
GSE291026
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/01/14
GPL16791
Summary
In this study, we investigated the role of the transcription factor FLI1 in megakaryopoiesis and examined how the newly identified pathological variant, FLI1 p.Met100*, disrupts megakaryocyte and platelet development. We hypothesized that FLI1 p.Met100* would generate a truncated peptide with a dominant negative effect. To test this, we ectopically expressed both wild-type FLI1 and FLI1 p.Met100* in Meg01 cells. Following succeful detection of the truncated peptide, RNA sequencing revealed that FLI1 p.Met100* upregulated erythroid genes, including KLF1, CD235a, and CD36, whereas wild-type FLI1 suppressed their expression.
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Paper (PMID 41497345) ↗
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