snRNA-seq dataset of 17 treatment-naive human PDAC patient-derived tumors
Single-nucleus RNA-seq · human · 17 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue).
- Organism
- Homo sapiens (human)
- Topic
- Pancreatic cancerThis series is part of our curated briefing on it.
- Samples
- 17 samples: 17 × PDAC Tumor Sample PDACGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Multimodal profiling of pancreatic cancer reveals a TIMP-1-dominated secretory profile determining pro-tumor immunoinstruction in human cancersCell reports. Medicine · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291124_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1230557 and SRA study SRP567635. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 17 samples.
How we read this: 1 replicated groups read from 17 sample titles; they account for 17 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8829421 PDAC Tumor Sample PDAC1 PDAC Tumor Sample PDAC
- GSM8829422 PDAC Tumor Sample PDAC2 PDAC Tumor Sample PDAC
- GSM8829423 PDAC Tumor Sample PDAC3 PDAC Tumor Sample PDAC
- GSM8829424 PDAC Tumor Sample PDAC4 PDAC Tumor Sample PDAC
- GSM8829425 PDAC Tumor Sample PDAC5 PDAC Tumor Sample PDAC
- GSM8829426 PDAC Tumor Sample PDAC6 PDAC Tumor Sample PDAC
- GSM8829427 PDAC Tumor Sample PDAC7 PDAC Tumor Sample PDAC
- GSM8829428 PDAC Tumor Sample PDAC8 PDAC Tumor Sample PDAC
- GSM8829429 PDAC Tumor Sample PDAC9 PDAC Tumor Sample PDAC
- GSM8829430 PDAC Tumor Sample PDAC10 PDAC Tumor Sample PDAC
- GSM8829431 PDAC Tumor Sample PDAC11 PDAC Tumor Sample PDAC
- GSM8829432 PDAC Tumor Sample PDAC12 PDAC Tumor Sample PDAC
- GSM8829433 PDAC Tumor Sample PDAC13 PDAC Tumor Sample PDAC
- GSM8829434 PDAC Tumor Sample PDAC14 PDAC Tumor Sample PDAC
- GSM8829435 PDAC Tumor Sample PDAC15 PDAC Tumor Sample PDAC
- GSM8829436 PDAC Tumor Sample PDAC16 PDAC Tumor Sample PDAC
- GSM8829437 PDAC Tumor Sample PDAC17 PDAC Tumor Sample PDAC
- GSE150043 Deeper insight into Pancreatic Ductal Adenocarcinoma (PDAC) survival heterogeneity using integrative analyses of individual and global transcriptome based networks 19 samples same disease briefing · shares pdac
- GSE101448 Microarray gene-expression data to identify a robust biomarker signature in PDAC and validate it in formalin-fixed paraffin-embedded tissue material. 43 samples same disease briefing · shares pdac
- GSE143584 Gene expression from laser capture microdissected epithelium and stroma during pancreatic carcinogenesis 366 samples same disease briefing
- GSE288221 RNA sequencing human melanoma, glioblastoma and pancreatic adenocarcinoma cell lines 32 samples same disease briefing
- GSE113616 Stromal Fibroblasts Drive Single Cell Heterogeneity in Pancreatic Cancer 189 samples same disease briefing
- GSE147549 Transcriptomic profiling of human pancreatic cancer-derived cell lines MiaPACA-2 depleted of TRIP12 mRNA compared to control cells 8 samples same disease briefing
- GSE179351 Radiation Therapy Inhances Immunotherapy Response in Microsatellite-stable Colorectal and Pancreatic Adenocarcinoma in a Phase II Trial 54 samples same disease briefing
- GSE148188 NOXA dependent induction of apoptosis in pancreatic cancer cells 49 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.