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IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma [ATAC-seq]

GSE291230 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/05/07 Platform GPL30172
Summary
Type 2 inflammation in the lung underlies allergic asthma and promotes tumor metastasis. Type 2 innate lymphoid cells (ILC2s) respond to tissue damage signals including IL-33 and IL-25 and are implicated in type 2 inflammatory diseases of the lung, but the factors that maintain ILC2s ability to produce type 2 cytokines are not known. We show Blimp-1 is a key transcriptional repressor of type 1 genes induced by the type 2 cytokine IL-9 in ILC2s in response to tissue damage signals. Loss of Blimp-1 in ILC2s altered inflammation in response to allergens, but also limited metastatic melanoma in the lung by limiting type 2 cytokines in favor of type I cytokines including IFNg and TNF. Thus, Blimp-1 protects the type 2 identity of ILC2s during lung inflammatory diseases.
Published in
IL-9 and Blimp-1 protects the transcriptional identity of group 2 innate lymphocytes in allergic asthma
Zheng Y, Zhang J, Yang A et al. · Research square 2025 · PMID 40297693 · doi:10.21203/rs.3.rs-6365283/v1
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Also filed as BioProject PRJNA1232619 and SRA study SRP568333. Searching any of these in the dataset finder brings you back here.

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