Glucagon controls obesity-specific energy expenditure via persistent cAMP/PKA signaling
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 6 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291382_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1233268 and SRA study SRP568697. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 4 samples read as cases, 12 as controls.
How we read this: 6 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8834072 wt-treated-1 wt-treated
- GSM8834073 ko-treated-1 ko-treated
- GSM8834074 wt-treated-2 wt-treated
- GSM8834075 ko-treated-2 ko-treated
- GSM8834076 wt-control-1 wt-control
- GSM8834077 ko-control-1 ko-control
- GSM8834078 wt-control-2 wt-control
- GSM8834079 ko-control-2 ko-control
- GSM8834080 wt-control-3 wt-control
- GSM8834081 ko-control-3 ko-control
- GSM8834082 wt-control-4 wt-control
- GSM8834083 ko-control-4 ko-control
- GSM8834084 wt-treated-3 wt-treated
- GSM8834085 ko-treated-3 ko-treated
- GSM8834086 wt-treated-4 wt-treated
- GSM8834087 ko-treated-4 ko-treated
- GSM8834088 B6N-vehicle-1 B6N-vehicle
- GSM8834089 B6N-vehicle-2 B6N-vehicle
- GSM8834090 B6N-vehicle-3 B6N-vehicle
- GSM8834091 B6N-vehicle-4 B6N-vehicle
- GSM8834092 B6N-86-5day-1 B6N-86-5day
- GSM8834093 B6N-86-5day-2 B6N-86-5day
- GSM8834094 B6N-86-5day-3 B6N-86-5day
- GSM8834095 B6N-86-5day-4 B6N-86-5day
- GSE291380 Glucagon controls obesity-specific energy expenditure via persistent cAMP/PKA signaling [RNA-Seq 1] 16 samples shares pka, obesity-specific, expenditure, persistent, glucagon, controls, energy, camp
- GSE291381 Glucagon controls obesity-specific energy expenditure via persistent cAMP/PKA signaling [RNA-Seq 2] 8 samples shares pka, obesity-specific, expenditure, persistent, glucagon, controls, energy, camp
- GSE292387 Medial preoptic PNOC neurons constrain brown adipose tissue thermogenesis and energy expenditure 10 samples shares expenditure, energy
- GSE247291 Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice 6 samples shares expenditure, energy
- GSE276975 The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice 6 samples shares expenditure, energy
- GSE315581 Wnt/β-catenin signaling restrains developmental beige adipocyte thermogenesis and its inhibition imprints long-term energy expenditure_Inguinal white adipose tissue (iWAT) from 4-week-old male mice 6 samples shares expenditure, energy
- GSE315583 Wnt/β-catenin signaling restrains developmental beige adipocyte thermogenesis and its inhibition imprints long-term energy expenditure_Primary adipocytes differentiated in vitro, 4- and 8-week-old male mice 6 samples shares expenditure, energy
- GSE306829 Medial preoptic PNOC neurons constrain brown adipose tissue thermogenesis and energy expenditure 6 samples shares expenditure, energy
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.