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Transcriptomic Analysis of CAD Cell Differentiation

GSE291553 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/12 Platform GPL21103
Summary
CAD cells were derived from Cath.a cells, a mouse central nervous system catecholaminergic cell line. Serum-starved CAD cells undergo morphological changes and resemble isolated neurons when observed by microscopy. We carried out an RNAseq transcriptomic analysis to examine differentiated CAD cells for expression signatures related to neuronal functions, identifying ~1900 transcripts whose expression changed with differentiation. Pathview analysis identified ~80 KEGG pathway gene sets that were differentially expressed, including upregulation of at least 13 neuron-related pathways. This dataset can be explored more deeply, allowing further investigation into expression changes relevant to studying neuronal functions in this easy-to-culture model system.
Published in
Transcriptomic Analysis of CAD Cell Differentiation
Cevallos CA, White AL, Fazio BA et al. · bioRxiv : the preprint server for biology 2025 · PMID 40161715 · doi:10.1101/2025.03.09.642086
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Also filed as BioProject PRJNA1234137 and SRA study SRP569195. Searching any of these in the dataset finder brings you back here.

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