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N6-Methyladenosine-Modified circPICALM Encodes a Protein That Promotes Intrahepatic Cholangiocarcinoma Metastasis

GSE291554 Homo sapiens Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing 6 samples Submitted 2026/04/15 Platform GPL24676
Summary
Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive primary liver cancer characterized by rapid progression and strong metastatic potential. Circular RNAs (circRNAs) are emerging as crucial regulators in the complex biology of cancer, yet their specific roles in ICC metastasis remain poorly defined. In this study, circRNA sequencing of paired primary and recurrent ICC tissues revealed that elevated expression of circRNA PICALM (circPICALM) is strongly linked to ICC metastasis and patient prognosis.
Published in
m6A-dependent translation of circPICALM encodes a novel metastasis-promoting oncoprotein in intrahepatic cholangiocarcinoma
Li H, Wang S, Dai F et al. · Molecular cancer 2026 · PMID 41776633 · doi:10.1186/s12943-026-02625-6
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Also filed as BioProject PRJNA1234138 and SRA study SRP569197. Searching any of these in the dataset finder brings you back here.

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