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Neoadjuvant anlotinib combined with PD-1 blockade therapy remodeling the microenvironment in advanced non-small cell lung cancer

GSE291670 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/31 Platform GPL24676
Summary
Neoadjuvant anlotinib combined with PD-1 blockade therapy can prolong the survival of patients, but the underlying mechanisms for the failure of patients to benefit from combination therapy remain to be explored. To explore the mechanism of drug resistance and predict patient response, we performed scRNA-seq from 6 NSCLC patients, including 3 post-treatment patients with major pathological response (MPR), and 3 Non-MPR patients to observe and analyze the dynamic changes of immune cells, stromal cells and cancer cells from the NSCLC patients who received neoadjuvant anlotinib combined with PD-1 blockade therapy and verified in an independent cohort.
Published in
scRNA-seq reveals that VEGF signaling mediates the response to neoadjuvant anlotinib combined with PD-1 blockade therapy in non-small cell lung cancer
Huang Z, Li L, Zhao X et al. · Journal of translational medicine 2025 · PMID 40281576 · doi:10.1186/s12967-025-06485-4
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Also filed as BioProject PRJNA1234625 and SRA study SRP569716. Searching any of these in the dataset finder brings you back here.

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