GEO series
Identification of β-catenin dependent and independent genes in an orthotopic model of pancreatic cancer
GSE291732
Homo sapiens
Expression profiling by high throughput sequencing
32 samples
2026/01/23
GPL21290
Summary
Wnt signaling regulates metazoan development and homeostasis, in part by β-catenin dependent activation and repression of a large number of genes. However, Wnt signaling also regulates genes independent of β-catenin, genes that are less well characterized. In this study, using a pan-Wnt inhibitor we performed a comprehensive transcriptome analysis in a Wnt-addicted orthotopic cancer model to delineate the β-catenin-dependent and independent arms of Wnt signaling. We find that while a large percentage of Wnt-regulated genes are regulated by β-catenin, ten percent of these genes are regulated independent of β-catenin. Interestingly, a large proportion of these β-catenin independent genes are Wnt-repressed.
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Paper (PMID 41601419) ↗
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