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HDAC7 promotes renal cancer metastasis by reprogramming branched-chain amino acid metabolism

GSE291765 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/03/20 Platform GPL11154
Summary
Clear cell renal cell carcinoma (ccRCC), the most common subtype of kidney cancer, exhibits significant metabolic reprogramming. We previously reported elevated HDAC7, a class II histone deacetylase, in ccRCC. Here, we demonstrate that HDAC7 promotes aggressive phenotypes and in vivo tumor progression in RCC. HDAC7 suppresses the expression of genes mediating branched-chain amino acid (BCAA) catabolism. Notably, lower expression of BCAA catabolism genes is strongly associated with worsened survival in ccRCC. Suppression of BCAA catabolism promotes expression of SNAIL1, a central mediator of aggressive phenotypes including migration and invasion. HDAC7-mediated suppression of the BCAA catabolic program promotes SNAI1 mRNA transcription via NOTCH signaling activation. Collectively, our findings provide new insights into the role of metabolic remodeling in ccRCC tumor progression.
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Also filed as BioProject PRJNA1235210 and SRA study SRP569893. Searching any of these in the dataset finder brings you back here.

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