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Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma

GSE291808 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/03/28 Platform GPL20301
Summary
This article highlights the development of an antibody targeting CD99 in diffuse midline gliomas (DMG). 1. RNA-seq: We performed bulk RNA sequencing of HSJD-GBM01 cells transduced with H3.3K27M and its paired isogenic H3.3-WT cell lines to find the genes altered due to the transduction with the K27M Mutation compared to isogenic H3-WT controls. 2. RNA-seq: We also performed bulk RNA sequencing of SU-DIPG04 cells transduced with short-hair pin RNA (shRNA) targeting CD99 and with transduced with non-target controls to find the genes altered due the knockdown of CD99 compared to those transduced with non-target controls.
Published in
Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma
Balakrishnan I, Madhavan K, Pierce A et al. · Cancer research 2025 · PMID 40424183 · doi:10.1158/0008-5472.CAN-24-5027
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Also filed as BioProject PRJNA1235273 and SRA study SRP569947. Searching any of these in the dataset finder brings you back here.

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