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Aberrant brain-type neuronal programs in large-cell pancreatic neuroendocrine carcinoma

GSE291816 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/05 Platform GPL24676
Summary
High-grade pancreatic neuroendocrine carcinoma (panNEC) is a rare, aggressive cancer with limited tissue availability. Single-nucleus transcriptomics of five large-cell panNECs revealed two interesting neuroendocrine cell states: one highly proliferative with an aberrant brain-specific neuronal differentiation program and another stress-responsive state enriched for heat stress, hypoxia, and glycolysis. Our findings suggest potential therapeutic vulnerabilities, highlighting the need to evaluate the efficacy of combination therapies.
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Direct links to NCBI, no account and no request form: the whole study as GSE291816_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1235285. Searching any of these in the dataset finder brings you back here.

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