GEO series
Pre-clinical optimization of MDM2 antagonist treatment of glioblastoma
GSE291870
Homo sapiens
Expression profiling by high throughput sequencing
47 samples
2026/03/31
GPL24676
Summary
In glioblastomas wildtype p53 is inhibited by MDM2 or MDM4 amplification, or deletion of CDKN2A (coding for MDM2 inhibitor p14ARF). MDM2 pharmacological antagonists (MDM2a) are currently in clinical trials for wt p53 glioblastoma. Here we test the hypotheses that GBM response to MDM2a will vary, and that transcriptional activation signatures in response to MDM2a will have predictive value and support the identification of mechanisms of resistance.
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