Dnmt3a-dependent de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells [RNA-seq]
DNA methylation · mouse · 12 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Dnmt3a-dependent de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cellsCell reports · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291910_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1235762 and SRA study SRP570301. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8844266 21075X1 WT_Tfh_1
- GSM8844267 21075X2 WT_Tfh_2
- GSM8844268 21075X3 WT_Tfh_3
- GSM8844269 21075X4 WT_Th1_1
- GSM8844270 21075X5 WT_Th1_2
- GSM8844271 21075X6 WT_Th1_3
- GSM8844272 21075X7 KO_Tfh_1
- GSM8844273 21075X8 KO_Th1_1
- GSM8844274 21075X9 KO_Tfh_2
- GSM8844275 21075X10 KO_Th1_2
- GSM8844276 21075X11 KO_Tfh_3
- GSM8844277 21075X12 KO_Th1_3
- GSE291914 Dnmt3a-dependent de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells 39 samples shares dnmt3a-dependent, functionality, methylation, commitment, preserves, enforces, lineage
- GSE298006 Stage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [RNA-Seq] 110 samples shares commitment, lineage, rna-seq
- GSE289192 Histone H4 lysine 20 tri-methylation safeguards breast cancer lineage fidelity and unfolded protein response [scRNA-seq] 12 samples shares methylation, lineage, rna-seq
- GSE166225 Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates [RNA-seq] 288 samples shares methylation, rna-seq
- GSE266509 A Bcl11a-driven mechanism maintaining hematopoietic stem cell functionality gives rise to dysfunction during aging [RNA-Seq] 52 samples shares functionality, rna-seq
- GSE296993 H3K9 di-methylation dynamics underlies mouse minor zygotic genome activation [RNA-seq of mESC] 50 samples shares methylation, rna-seq
- GSE292282 H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells [RNA-Seq] 44 samples shares methylation, rna-seq
- GSE229238 DNA methylation constrains nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos [RNA-seq 2] 42 samples shares methylation, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.