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SRCAP mutation promotes cutatneous squamous cell carcinoma invasion [ChIP-Seq]

GSE292167 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/08/01 Platform GPL20301
Summary
In this study, we identify a mutational hotspot affecting SRCAP in cancer and that SRCAP is recurrently mutated in keratinocyte carcinomas. When introduced to primary human epidermal keratinocytes, the SRCAP hotspot mutation dysregulates gene expression in the differentiated state far more than the progenitor state. Gene dysregulation occurs without a change in H2A.Z chromatin occupancy. Finall, the presence of the SRCAP mutation in a RAS-CDK4 driven model of cSCC increases invasion significantly.
Published in
A dominant SRCAP truncating mutation promotes squamous cell carcinoma progression
Droll SH, Dewar EIO, Xue C et al. · Oncogenesis 2025 · PMID 40858549 · doi:10.1038/s41389-025-00576-z
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Also filed as BioProject PRJNA1237316 and SRA study SRP570921. Searching any of these in the dataset finder brings you back here.

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