Regulation of NK cell transcriptome by Hif1a and Ahr under hypoxia

NK cells responses can be significantly affected by microenvironmental conditions. In pathological conditions, oxygen concentration in tissues can be reduced, lading to hypoxia. Cells adapt to hypoxia by stabilizing transcription factor HIF-1a that mediates its regulatory functions by modifying gene transcription. In many cells, HIF-1a pathway intersect with the activation of the transcription factor AhR due to shared transcriptional co-activator. Here, we investigated how HIF-1a and AhR regulate murine NK cell transcriptome under hypoxia.