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Multi-omics Identifies Tumor-Intrinsic SREBP1 Driving Immune Exclusion in Hepatocellular Carcinoma

GSE292298 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/24 Platform GPL34284
Summary
Immune checkpoint inhibitors (ICI) have improved patient outcomes in hepatocellular carcinoma (HCC); however most patients do not experience durable benefit. The non-T cell-inflamed tumor microenvironment (TME), characterized by limited CD8+ T cell infiltration, reduced dendritic cell function, and low IFNγ-associated gene expression, is associated with lower likelihood of response to ICI. To nominate new therapeutic targets for overcoming ICI resistance in HCC, we conduced single cell RNAseq using 10X Genomics on 6 primary HCC tumors.
Published in
Multiomics identifies tumor-intrinsic SREBP1 driving immune exclusion in hepatocellular carcinoma
Dadey RE, Li R, Griner J et al. · Journal for immunotherapy of cancer 2025 · PMID 40518290 · doi:10.1136/jitc-2025-011537
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Direct links to NCBI, no account and no request form: the whole study as GSE292298_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1237847. Searching any of these in the dataset finder brings you back here.

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