GEO series
ALS-associated RNA binding proteins converge on UNC13A transcription through regulation of REST
GSE292352
Homo sapiens
Expression profiling by high throughput sequencing
10 samples
2025/07/21
GPL16791
Summary
Amyotrophic lateral sclerosis (ALS) is characterized by motor neuron degeneration. We demonstrate that ALS-associated RNA-binding proteins (RBPs)—MATR3, FUS, and hnRNPA1—regulate UNC13A transcription via REST mRNA stabilization. Loss of these RBPs increases REST levels, repressing UNC13A transcription and implicating synaptic dysfunction in ALS pathogenesis.
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Paper (PMID 40707625) ↗
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