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Gene expression changes upon Dot1L knockdown and Dot1L inhibitor treatment during reprogramming

GSE29253 Homo sapiens Expression profiling by array 26 samples Submitted 2012/03/01 Platform GPL571Platform GPL3921
Summary
Through a loss-of-function approach, we identified that inhibition of the histone methyltransferase, Dot1L, accelerated somatic cell reprogramming, significantly increased the yield of induced pluripotent stem (iPS) cell colonies, and substituted for Klf4 and c-Myc in the reprogramming cocktail. To understand the mechanism by which Dot1L inhibition results in these phenotypes, we carried out gene expression profiling using Affymetrix microarrays.
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Also filed as BioProject PRJNA139971. Searching any of these in the dataset finder brings you back here.

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