GEO series
Epithelial interferon-stimulated gene programs modulate chemotherapy sensitivity in colorectal cancer via EPSTI1
GSE292601
Homo sapiens
Expression profiling by high throughput sequencing
62 samples
2026/06/30
GPL24676
Summary
Precision oncology research typically utilizes patient-derived tumor organoids (PDTO) to predict clinical outcomes, but such efforts are often not directed towards identification of molecular factors underlying differential responses to therapy. Here, we performed bulk RNA-sequencing on treatment-naive PDTOs and combined gene expression data with in vitro drug response data to identify transcriptomic features and programs associated with low chemosensitivity.
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