Macrophage sensitivity to reprogramming by bexmarilimab is shaped by the tumor microenvironment [scRNA-Seq]
Single-cell RNA-seq · human · 10 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Homo sapiens (human)
- Samples
- 10 samples: 5 × Breast cancer tumor tissue, patient vs 5 × Adjacent breast tissue, patientGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Macrophage sensitivity to bexmarilimab-induced reprogramming is shaped by the tumor microenvironmentJournal for immunotherapy of cancer · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE292824_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1241314 and SRA study SRP572743. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8866032 Breast cancer tumor tissue, patient 85 Breast cancer tumor tis…
- GSM8866033 Adjacent breast tissue, patient 85 Adjacent breast tissue,…
- GSM8866034 Breast cancer tumor tissue, patient 92 Breast cancer tumor tis…
- GSM8866035 Adjacent breast tissue, patient 92 Adjacent breast tissue,…
- GSM8866036 Breast cancer tumor tissue, patient 95 Breast cancer tumor tis…
- GSM8866037 Adjacent breast tissue, patient 95 Adjacent breast tissue,…
- GSM8866038 Breast cancer tumor tissue, patient 98 Breast cancer tumor tis…
- GSM8866039 Adjacent breast tissue, patient 98 Adjacent breast tissue,…
- GSM8866040 Breast cancer tumor tissue, patient 99 Breast cancer tumor tis…
- GSM8866041 Adjacent breast tissue, patient 99 Adjacent breast tissue,…
- GSE309595 Longitudinal Analysis of Multiple Myeloma: Therapeutic Response and Immune Microenvironment Dynamics in the Context of Tumor Heterogeneity [scRNA-seq] 270 samples shares microenvironment, scrna-seq
- GSE297041 Chemoradiation Reprograms Tumor Cells and Immune Microenvironment In Cervical Cancer [scRNA-seq] 18 samples shares microenvironment, scrna-seq
- GSE294016 A macrophage-predominant, immunosuppressive immune microenvironment and subtype-specific therapeutic vulnerabilities in advanced salivary gland cancer [bulk RNA-seq] 95 samples shares microenvironment, macrophage
- GSE326661 Reprogramming engineered autologous T cells to overcome resistance in Merkel cell carcinoma [scRNA-seq] 22 samples shares reprogramming, scrna-seq
- GSE261322 NF-κB- and TET2-mediated macrophage reprogramming overrides the anti-inflammatory effects of hypoxia and improves responses in human cancer (RNA-Seq I). 20 samples shares reprogramming, macrophage
- GSE294017 A macrophage-predominant, immunosuppressive immune microenvironment and subtype-specific therapeutic vulnerabilities in advanced salivary gland cancer [Single nuclei RNAseq] 16 samples shares microenvironment, macrophage
- GSE279750 ACE2 Enhances Sensitivity to PD-L1 Blockade by Inhibiting Macrophage-Induced Immunosuppression and Angiogenesis [RNA-seq, anti-PD-L1 therapy] 10 samples shares sensitivity, macrophage
- GSE307326 Continuous NRTI-based antiretroviral therapy induces progressive senescence-like reprogramming of alveolar macrophages [snMultiomics] 32 samples shares reprogramming, macrophage
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.