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AT3 RNA-seq

GSE292849 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/11/06 Platform GPL17021
Summary
ER+ breast cancer is the most prevalent subtype of the disease with improved prognosis thanks to advances in target therapies against the main driver of proliferation, estrogen receptor (ER). Despite all the advances in the study of this subtype, murine models that allow to study the interaction of tumor cells with the stromal compartment are merely absent. In this study we aimed to ectopically overexpresse the protein ER in AT3 murine cell line and check the ability to resemble ER+ breast cancer cells. We compared the transcriptomic profile of ER-OE cells versus control.
Published in
Estrogen receptor signaling drives immune evasion and immunotherapy resistance in HR+ breast cancer
Palomeque JÁ, Serra-Mir G, Blasco-Benito S et al. · The Journal of clinical investigation 2026 · PMID 41289011 · doi:10.1172/JCI193153
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Direct links to NCBI, no account and no request form: the whole study as GSE292849_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1241734 and SRA study SRP572938. Searching any of these in the dataset finder brings you back here.

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