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Genomic Localization of RUNX Proteins in Neonatal Germ Cells.

GSE292902 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 7 samples Submitted 2026/02/26 Platform GPL30172
Summary
Prior studies by our group demonstrated the essential role of core-binding factor subunit β (CBFβ) in prepubertal male germline development. CBFβ is a common co-factor to the runt-related family of transcription factors (RUNX), of which RUNX1 and RUNX3 are expressed in prepubertal germ cells. Therefore, to gain insights into the functional roles of CBFβ and RUNX proteins in the male germline, we conducted cleavage under targets & release using nuclease (CUT&RUN) for CBFβ, RUNX1, and RUNX3 within male germ cells. Collectively, our analyses revealed both unique and overlapping genomic localizations of CBFβ and RUNX1/3 in male germ cells.
Published in
RUNX proteins and CBFβ create an interconnected network of transcriptional regulation in the male germline†
Rahmawati M, Black CJ, Dalvi DD et al. · Biology of reproduction 2026 · PMID 41575177 · doi:10.1093/biolre/ioag021
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Also filed as BioProject PRJNA1241833 and SRA study SRP573113. Searching any of these in the dataset finder brings you back here.

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