Selective CDK7 Inhibition Sensitizes Tumors to Topoisomerase I Inhibitor-Antibody Drug Conjugates by Blocking The Transition of The RNA polymerase II Initiation Complex into Elongation [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 97 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 97 samples: 61 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Sensitizing tumor response to topoisomerase I antibody drug conjugate by selective CDK7 inhibitionbioRxiv : the preprint server for biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE292907_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1241844 and SRA study SRP573025. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 125 samples.
How we read this: 61 replicated groups read from 125 sample titles; they account for 125 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8869056 pan pol II, Ser5P, Ser2P 1h input rep1 pan pol II, Ser5P, Ser2…
- GSM8869057 pan pol II DMSO 1h, EtOH 1h rep1 pan pol II DMSO 1h, EtO…
- GSM8869058 pan pol II Q901 1h, EtOH 1h rep1 pan pol II Q901 1h, EtO…
- GSM8869059 Ser5P DMSO 1h, EtOH 1h rep1 Ser5P DMSO 1h, EtOH 1h
- GSM8869060 Ser5P Q901 1h, EtOH 1h rep1 Ser5P Q901 1h, EtOH 1h
- GSM8869061 Ser2P DMSO 1h, EtOH 1h rep1 Ser2P DMSO 1h, EtOH 1h
- GSM8869062 Ser2P Q901 1h, EtOH 1h rep1 Ser2P Q901 1h, EtOH 1h
- GSM8869063 pan pol II, Ser5P, Ser2P 1h input rep2 pan pol II, Ser5P, Ser2…
- GSM8869064 pan pol II DMSO 1h, EtOH 1h rep2 pan pol II DMSO 1h, EtO…
- GSM8869065 pan pol II Q901 1h, EtOH 1h rep2 pan pol II Q901 1h, EtO…
- GSM8869066 Ser5P DMSO 1h, EtOH 1h rep2 Ser5P DMSO 1h, EtOH 1h
- GSM8869067 Ser5P Q901 1h, EtOH 1h rep2 Ser5P Q901 1h, EtOH 1h
- GSM8869068 Ser2P DMSO 1h, EtOH 1h rep2 Ser2P DMSO 1h, EtOH 1h
- GSM8869069 Ser2P Q901 1h, EtOH 1h rep2 Ser2P Q901 1h, EtOH 1h
- GSM8869070 CDK7 1h input rep1 CDK7 1h input
- GSM8869071 CDK7 DMSO 1h, EtOH 1h rep1 CDK7 DMSO 1h, EtOH 1h
- GSM8869072 CDK7 Q901 1h, EtOH 1h rep1 CDK7 Q901 1h, EtOH 1h
- GSM8869073 CDK7 1h input rep2 CDK7 1h input
- GSM8869074 CDK7 DMSO 1h, EtOH 1h rep2 CDK7 DMSO 1h, EtOH 1h
- GSM8869075 CDK7 Q901 1h, EtOH 1h rep2 CDK7 Q901 1h, EtOH 1h
- GSM8869076 CDK7 1h input rep3 CDK7 1h input
- GSM8869077 CDK7 DMSO 1h, EtOH 1h rep3 CDK7 DMSO 1h, EtOH 1h
- GSM8869078 CDK7 Q901 1h, EtOH 1h rep3 CDK7 Q901 1h, EtOH 1h
- GSM8869079 MYC 1h input rep1 MYC 1h input
- GSM8869080 MYC DMSO 1h, EtOH 1h rep1 MYC DMSO 1h, EtOH 1h
- GSM8869081 MYC Q901 1h, EtOH 1h rep1 MYC Q901 1h, EtOH 1h
- GSM8869082 MYC 1h input rep2 MYC 1h input
- GSM8869083 MYC DMSO 1h, EtOH 1h rep2 MYC DMSO 1h, EtOH 1h
- GSM8869084 MYC Q901 1h, EtOH 1h rep2 MYC Q901 1h, EtOH 1h
- GSM8869085 E2F1 1h input rep1 E2F1 1h input
- GSM8869086 E2F1 DMSO 1h, EtOH 1h rep1 E2F1 DMSO 1h, EtOH 1h
- GSM8869087 E2F1 Q901 1h, EtOH 1h rep1 E2F1 Q901 1h, EtOH 1h
- GSM8869088 E2F1 1h input rep2 E2F1 1h input
- GSM8869089 E2F1 DMSO 1h, EtOH 1h rep2 E2F1 DMSO 1h, EtOH 1h
- GSM8869090 E2F1 Q901 1h, EtOH 1h rep2 E2F1 Q901 1h, EtOH 1h
- GSM8869091 pan pol II, Ser5P, Ser2P, CDK7 4h, 24h input rep1 pan pol II, Ser5P, Ser2…
- GSM8869092 pan pol II DMSO 4h rep1 pan pol II DMSO 4h
- GSM8869093 pan pol II Q901 4h rep1 pan pol II Q901 4h
- GSM8869094 pan pol II DMSO 24h rep1 pan pol II DMSO 24h
- GSM8869095 pan pol II Q901 24h rep1 pan pol II Q901 24h
+ 57 more — browse all 97 samples with per-sample file links →
- GSE218269 CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release 100 samples shares cdk7, polymerase
- GSE228346 The TFIIH kinase CDK7 governs RNA polymerase II initiation, elongation, termination, and RNA processing 30 samples shares cdk7, polymerase
- GSE277437 Effects of CDK7 inhibition on fibrotic gene expression 12 samples shares cdk7, inhibition
- GSE303106 Prolonged KRAS-MAPK Inhibition Induces Interferon-mediated Epithelial-to-Mesenchymal Transition and Reveals Therapeutic Opportunities [cut and run-ChipSeq] 9 samples shares inhibition, transition
- GSE303051 Prolonged KRAS-MAPK Inhibition Induces Interferon-mediated Epithelial-to-Mesenchymal Transition and Reveals Therapeutic Opportunities. 30 samples shares inhibition, transition
- GSE185651 Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance 28 samples shares inhibition, sensitizes
- GSE285406 ZNF274 constrains lineage plasticity and drives intrinsic resistance to CDK7 inhibitors in pancreatic cancer 48 samples shares cdk7
- GSE279730 Gene expression analysis of prostate cancer cells resistant to CDK7 inhibitors 12 samples shares cdk7
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.