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RNF25-Mediated NF-κB Activation Drives Anti-Apoptosis and Therapy Resistance in Cancer [ChIP-seq]

GSE293002 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/03/26 Platform GPL24676
Summary
Dysregulation of the NF-κB pathway is frequently observed in cancers, contributing to therapy resistance by inhibiting apoptosis. In this study, we identify RNF25, an E3 ubiquitin ligase, as a key regulator of signal transduction, inflammation, immune responses, and apoptosis. RNA sequencing (RNA-seq) analysis following RNF25 knockdown revealed significant alterations in key apoptotic regulators and NF-κB signaling components, highlighting the role of RNF25 in apoptotic resistance and therapeutic response. Pathway enrichment analysis further demonstrated disruptions in pro-survival and inflammatory signaling pathways, suggesting that RNF25 knockdown enhances apoptotic sensitivity and may influence treatment efficacy. This dataset provides valuable insights into potential therapeutic targets for overcoming treatment resistance.
Published in
BAY11-7082 Targets RNF25 to Reverse TRIP4 Ubiquitination-dependent NF-κB Activation and Apoptosis Resistance in Renal Cell Carcinoma
Li L, Wang Z, Ma B et al. · International journal of biological sciences 2025 · PMID 40765826 · doi:10.7150/ijbs.115032
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Also filed as BioProject PRJNA1242338 and SRA study SRP573333. Searching any of these in the dataset finder brings you back here.

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