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Examining the transcriptional changes thar result from loss of p53 in mutant p53 A431 cells

GSE293711 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/07/09 Platform GPL21697
Summary
A431 mutant p53 cells are able to engulf neighbouring cancer cells. Loss of p53 in these cells impairs this behaviour. To determine if transcriptional changes could underlie these phenotypic changes we compared A431 cells in which p53 was deleted using CRISPR (p53 KO) to parental cells (P) or cells that were transfected with a CRISP control construct (p53 ctr). Three indivicual clones were derived from single cells and compared to each other.
Published in
Mutant p53 induces SH3BGRL expression to promote cell engulfment
Dolma L, Patterson MI, Banyard A et al. · Cell death discovery 2025 · PMID 40592808 · doi:10.1038/s41420-025-02582-x
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Also filed as BioProject PRJNA1246068 and SRA study SRP576276. Searching any of these in the dataset finder brings you back here.

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