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Single-Cell Transcriptomics Matrix of all PBMC samples used in “Single-Cell Transcriptomics Reveals Immune Dysregulation in HIV-MTB Co-Infection: CD4+ T Cells Exhaustion and CD8+ T Cells Hyperactivation”

GSE293960 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/04/12 Platform GPL24676
Summary
To investigate the early immune profiles of patients, particularly those with HIV and tuberculosis co-infection, we collected blood samples from three individuals in the HIV/MTB co-infection group, three HIV/AIDS patients, and three healthy controls. Peripheral blood mononuclear cells (PBMCs) were isolated, and the MobiNova®-100 Single Cell System (MobiDrop (Zhejiang) Co., Ltd.) was employed to prepare single-cell sequencing libraries. Subsequently, a single-cell RNA expression matrix was generated using the Illumina NovaSeq 6000 System, yielding a total of 113,816 cells for further analysis.
Published in
Single-cell transcriptomics reveals pathogen interactions and T cell reprogramming in HIV and Mycobacterium tuberculosis co-infection
Zhao Z, Huang S, Huang W et al. · Frontiers in immunology 2025 · PMID 41394852 · doi:10.3389/fimmu.2025.1680538
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Direct links to NCBI, no account and no request form: the whole study as GSE293960_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1247497. Searching any of these in the dataset finder brings you back here.

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