GEO series
Histon lactylation drives HAS2 expression in gastric cancer tumorigensis after H.pylori infection
GSE293976
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/04/09
GPL16791
Summary
Histone lactylation, an epigenetic modification, promotes tumor growth and immune evasion in various cancers. Our study found increased pan-lysine lactylation and H3K18la in gastric tissues, linked to poor prognosis. Inhibiting glycolysis and silencing lactate dehydrogenase reduced H3K18la, boosting CD8+ T-cell activity against gastric cancer. H3K18la activated HAS2 transcription, enhancing MYC nuclear transport and PD-L1 expression..Our data provide a molecular framework for Histone lactylation in the process of gastric cancer.
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